Guagnano M T, Di Vincenzo M, Sensi S
Boll Soc Ital Biol Sper. 1982 Jun 30;58(12):736-9.
In order to evaluate if a weight-reducing drug,-fenfluramine-(F.), administrated in different times of a day, provokes different rates of body weight reduction, it has been given in a group of obese patients according to 3 protocols: in the morning as a single dose of 80 mg. (Pr. M.); in the afternoon as a single dose of 80 mg. (Pr. A); and three times a day, at 08.00, 13.00 and 20.00 (Pr. T.T.). The administration of a single dose in the morning for 4 weeks provokes a higher decrease of body weight compared with the administration of the drug in the afternoon or three times a day for an equivalent period of time, (p less than 0.01; p less than 0,05). In addition the decrease in body weight appears significantly correlated with the decrease of adipose mass, obtained according to Hume and Weyers formulae. These preliminary results suggest to study the eating behaviour in order to observe if fenfluramine, which is known to affect the eating behaviour, changes its efficacy according to the time of administration and consequently its activity on body weight and adipose mass.
为了评估一种减肥药物——芬氟拉明（F.）在一天中的不同时间给药是否会引起不同的体重减轻速率，已按照3种方案在一组肥胖患者中给予该药物：早上单次服用80毫克（方案M）；下午单次服用80毫克（方案A）；以及一天三次，分别在08:00、13:00和20:00服用（方案T.T.）。与在下午或在相同时间段内一天三次给药相比，早上单次给药4周会引起更高的体重下降（p小于0.01；p小于0.05）。此外，体重下降似乎与根据休谟和韦耶斯公式获得的脂肪量减少显著相关。这些初步结果建议研究进食行为，以观察已知会影响进食行为的芬氟拉明是否会根据给药时间改变其疗效，从而改变其对体重和脂肪量的作用。
