Di Vincenzo M, Guagnano M T, Della Loggia F, Sensi S
Boll Soc Ital Biol Sper. 1982 Jun 30;58(12):740-4.
The administration of Fenfluramine (F.) in a single dose in the morning provokes a different effect on eating behavior (E.B.) in comparison with the administration of the same dose three times/day. It is observed a shorter duration of eating (p less than 001); a decrease of total kcalories ingested during the day, and hunger feeling. These results are reviewed on the basis of present knowledge on drug-kinetic and on previous work in our laboratory which documented higher decrease of body weight and adipose mass when the F. was administered in a single dose in the morning than in the afternoon or three times a day.
与每日三次服用相同剂量的芬氟拉明相比，早上单次服用芬氟拉明（F.）对进食行为（E.B.）产生不同的影响。观察到进食持续时间更短（p小于0.001）；白天摄入的总卡路里减少，饥饿感降低。根据目前关于药物动力学的知识以及我们实验室之前的工作对这些结果进行了综述，之前的工作记录了早上单次服用芬氟拉明比下午或一天三次服用时体重和脂肪量的降低幅度更大。
