抗高血压药物与血脂：奥斯陆研究
Antihypertensive drugs and blood lipids: the Oslo study.
作者信息
Leren P, Eide I, Foss O P, Helgeland A, Hjermann I, Holme I, Kjeldsen S E, Lund-Larsen P G
出版信息
Br J Clin Pharmacol. 1982;13(Suppl 2):441S-444S. doi: 10.1111/j.1365-2125.1982.tb01954.x.
Abstract
1 The report presents the effects on blood lipids and uric acid of six different antihypertensive drugs, used alone and of five different combinations of two antihypertensive drugs. 2 Prazosin significantly lowered serum LDL + VLDL cholesterol and total triglycerides. Atenolol lowered LDL + VLDL cholesterol to a smaller but significant extent. Both pindolol and hydrochlorothiazide (HCTH) were without effect, while oxprenolol significantly increased total triglycerides. Propranolol significantly lowered HDL cholesterol and increased total triglycerides and uric acid. 3 The combination prazosin and pindolol had a favourable effect on the lipid profile, while the combination propranolol and HCTH lowered HDL cholesterol but increased total triglycerides. Propranolol and prazosin lowered HDL cholesterol, while methyldopa and HCTH, and HCTH and amiloride were without effect on blood lipids. 4 It is suggested that the metabolic effects of antihypertensive drugs could be of special importance in long-term treatment of mild hypertension.
摘要
- 本报告介绍了六种不同的抗高血压药物单独使用以及五种不同的两种抗高血压药物组合对血脂和尿酸的影响。2. 哌唑嗪显著降低血清低密度脂蛋白+极低密度脂蛋白胆固醇和总甘油三酯。阿替洛尔使低密度脂蛋白+极低密度脂蛋白胆固醇有较小但显著的降低。吲哚洛尔和氢氯噻嗪（HCTH）均无作用，而氧烯洛尔显著增加总甘油三酯。普萘洛尔显著降低高密度脂蛋白胆固醇，并增加总甘油三酯和尿酸。3. 哌唑嗪和吲哚洛尔组合对血脂谱有有利影响，而普萘洛尔和氢氯噻嗪组合降低高密度脂蛋白胆固醇但增加总甘油三酯。普萘洛尔和哌唑嗪降低高密度脂蛋白胆固醇，而甲基多巴和氢氯噻嗪以及氢氯噻嗪和阿米洛利对血脂无影响。4. 有人提出，抗高血压药物的代谢作用在轻度高血压的长期治疗中可能具有特殊重要性。
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