阿替洛尔和普萘洛尔治疗原发性高血压的代谢后果。
Metabolic consequences of atenolol and propranolol in treatment of essential hypertension.
作者信息
Day J L, Simpson N, Metcalfe J, Page R L
出版信息
Br Med J. 1979 Jan 13;1(6156):77-80. doi: 10.1136/bmj.1.6156.77.
Abstract
A six-month study of triglyceride, cholesterol, free fatty acid (FFA), glucose, insulin, growth hormone, and glucagon concentrations was carried out in asymptomatic hypertensive normal-weight men randomly allocated to treatment with atenolol or propranolol. A highly significant increase in the basal plasma triglyceride concentration was observed in propranolol-treated patients after three and six months' treatment, with a smaller but significant increase in atenolol-treated subjects after six months' treatment. The changes in triglyceride concentration could not be ascribed to variations in plasma insulin, growth hormone, or glucagon concentrations. Basal FFA concentrations were reduced during the first three months of treatment in both groups but returned to pretreatment levels after six months. Plasma cholesterol concentrations were unchanged by either agent.
摘要
对随机分配接受阿替洛尔或普萘洛尔治疗的无症状高血压正常体重男性进行了一项为期六个月的研究，测定其甘油三酯、胆固醇、游离脂肪酸（FFA）、葡萄糖、胰岛素、生长激素和胰高血糖素的浓度。在接受普萘洛尔治疗的患者中，治疗三个月和六个月后，基础血浆甘油三酯浓度显著升高；在接受阿替洛尔治疗的受试者中，治疗六个月后甘油三酯浓度有较小但显著的升高。甘油三酯浓度的变化不能归因于血浆胰岛素、生长激素或胰高血糖素浓度的变化。两组治疗的前三个月基础FFA浓度均降低，但六个月后恢复到治疗前水平。两种药物对血浆胆固醇浓度均无影响。
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本文引用的文献
1
The effect of physical training on insulin production in obesity.体育锻炼对肥胖者胰岛素分泌的影响。
Metabolism. 1970 Aug;19(8):631-8. doi: 10.1016/0026-0495(70)90020-x.
2
Propranolol and hypertriglyceridemia.普萘洛尔与高甘油三酯血症
Atherosclerosis. 1973 Jan-Feb;17(1):31-5. doi: 10.1016/0021-9150(73)90132-9.
3
The effect of beta-adrenergic blocking agents on serum lipids.β-肾上腺素能阻滞剂对血脂的影响。
Atherosclerosis. 1971 Sep-Oct;14(2):283-7. doi: 10.1016/0021-9150(71)90057-8.
4
On sympathetic regulation of carbohydrate metabolism in the liver.论肝脏中碳水化合物代谢的交感神经调节
J Pharm Pharmacol. 1965 Dec;17(12):805-8. doi: 10.1111/j.2042-7158.1965.tb07609.x.
5
[Effect of beta sympatholytic agent ICI 50172 (Dalzic) in various cardiovascular diseases].β-肾上腺素能阻滞剂ICI 50172（达齐克）在各种心血管疾病中的作用
Med Klin. 1973 May 11;68(19):634-41.
6
Elevation of serum lipid levels during diuretic therapy of hypertension.高血压利尿治疗期间血清脂质水平的升高。
Am J Med. 1976 Nov;61(5):748-57. doi: 10.1016/0002-9343(76)90156-x.
7
The metabolic consequences of adrenergic blockade: a reveiw.肾上腺素能阻滞剂的代谢后果：一篇综述。
Metabolism. 1975 Aug;24(8):987-96. doi: 10.1016/0026-0495(75)90090-6.
8
Effect of chronic administration of propranolol on lipoprotein composition.慢性给予普萘洛尔对脂蛋白组成的影响。
Metabolism. 1976 Oct;25(10):1071-5. doi: 10.1016/0026-0495(76)90014-7.
9
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Lancet. 1975 Jan 4;1(7897):9-10. doi: 10.1016/s0140-6736(75)92372-7.
10
Beta-blockers and lipid metabolism.β受体阻滞剂与脂质代谢
Br Med J. 1977 Jul 9;2(6079):126. doi: 10.1136/bmj.2.6079.126-a.
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