Gabka J, Price R K
Br J Clin Pharmacol. 1982 Jul;14(1):104-6. doi: 10.1111/j.1365-2125.1982.tb04943.x.
A dose-ranging study of meptazinol was carried out using the pain threshold to electrical tooth pulp stimulation in healthy volunteers as the pain model. A well defined dose-response curve was found for oral meptazinol (50 mg, 100 mg, 150 mg and 200 mg) and placebo. The methodology and results are discussed in terms of subsequent clinical experience with meptazinol.
以健康志愿者对牙髓电刺激的疼痛阈值作为疼痛模型，开展了美普他酚的剂量范围研究。对于口服美普他酚（50毫克、100毫克、150毫克和200毫克）和安慰剂，发现了明确的剂量反应曲线。根据美普他酚随后的临床经验对该方法和结果进行了讨论。
