OPT：一套用于临床药代动力学参数优化的计算机程序。
OPT: a package of computer programs for parameter optimisation in clinical pharmacokinetics.
作者信息
Kelman A W, Whiting B, Bryson S M
出版信息
Br J Clin Pharmacol. 1982 Aug;14(2):247-56. doi: 10.1111/j.1365-2125.1982.tb01969.x.
Abstract
1 OPT is a series of computer programs designed to assist dose optimisation for individual patients. It is based on Bayesian Statistical Theory and Maximum Likelihood Estimation. 2 OPT uses prior information on the distribution of population pharmacokinetic parameters and plasma drug concentration measurements to obtain the "most likely' set of parameters for the individual. 3 Complex dosage regimes and non-steady state conditions can be handled. 4 OPT is designed for use in a Clinical Pharmacokinetics Laboratory where informed interpretation of results is essential. 5 The drugs for which the system is currently available include theophylline, digoxin, lignocaine, disopyramide, gentamicin and phenytoin (steady state data only).
摘要
OPT是一系列旨在协助个体患者剂量优化的计算机程序。它基于贝叶斯统计理论和最大似然估计。
OPT利用群体药代动力学参数分布的先验信息和血浆药物浓度测量值来获取个体的“最可能”参数集。
可以处理复杂的给药方案和非稳态情况。
OPT设计用于临床药代动力学实验室，在那里对结果进行明智的解释至关重要。
该系统目前适用的药物包括茶碱、地高辛、利多卡因、丙吡胺、庆大霉素和苯妥英（仅稳态数据）。
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本文引用的文献
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