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个体收缩期时间间隔与心率回归方程的预测。

The prediction of individual systolic time interval v heart rate regression equations.

作者信息

Kelman A W, Sumner D J, Whiting B

出版信息

Br J Clin Pharmacol. 1981 Jul;12(1):21-30. doi: 10.1111/j.1365-2125.1981.tb01850.x.

Abstract
  1. Twenty-eight sets of systolic time interval (STI) and heart rate (HR) data were available from studies in which small bolus doses of atropine had been given to alter heart rate. 2. Regression lines of the form LVET = A+B.HR and QS2 = C+D.HR were calculated. There was no significant relationship between PEP and HR. The values of the parameters A-D were normally distributed. 3. The maximum likelihood Estimation was used to obtain the most likely values of the parameters A-D for individual subjects. 4. The technique proved to be highly satisfactory and was subsequently validated with a further six sets of data.
摘要
  1. 从给予小剂量推注阿托品以改变心率的研究中获得了28组收缩期时间间期(STI)和心率(HR)数据。2. 计算了LVET = A + B.HR和QS2 = C + D.HR形式的回归线。PEP与HR之间无显著关系。参数A - D的值呈正态分布。3. 使用最大似然估计来获得个体受试者参数A - D的最可能值。4. 该技术被证明非常令人满意,随后用另外六组数据进行了验证。

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本文引用的文献

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Comparative pharmacokinetics and pharmacodynamics of cardiac glycosides.强心苷的比较药代动力学和药效学
Br J Clin Pharmacol. 1980 Aug;10(2):135-43. doi: 10.1111/j.1365-2125.1980.tb01730.x.
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Systolic time intervals in heart failure in man.人类心力衰竭时的收缩期时间间期
Circulation. 1968 Feb;37(2):149-59. doi: 10.1161/01.cir.37.2.149.
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Left ventricular function in chronic renal failure.慢性肾衰竭患者的左心室功能
Br Heart J. 1976 Dec;38(12):1229-39. doi: 10.1136/hrt.38.12.1229.
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Pharmacokinetics of beta-methyldigoxin in healthy humans III: Pharmacodynamic correlations.
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