地高辛的代谢与吸收部位。
Metabolism of digoxin and absorption site.
作者信息
Magnusson J O, Bergdahl B, Bogentoft C, Jonsson U E
出版信息
Br J Clin Pharmacol. 1982 Aug;14(2):284-5. doi: 10.1111/j.1365-2125.1982.tb01976.x.
Abstract
After oral intake of enteric-coated granules containing [3H]-digoxin extensive metabolism was observed. Maximum 66% of the 24 h urinary excretion was identified as [3H]-dihydrodigoxin, using high performance liquid chromatography for the analysis. It is suggested that metabolism of digoxin may depend on the absorption site.
摘要
口服含[3H]-地高辛的肠溶颗粒后，观察到广泛的代谢。使用高效液相色谱法进行分析，发现24小时尿排泄量中最高有66%被鉴定为[3H]-二氢地高辛。提示地高辛的代谢可能取决于吸收部位。
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