Huupponen R, Seppälä P, Iisalo E
Eur J Clin Pharmacol. 1984;26(2):279-81. doi: 10.1007/BF00630301.
The effect of guar gum on the absorption of digoxin and phenoxymethyl penicillin was studied in a double blind study in 10 healthy volunteers. Guar gum reduced serum digoxin concentration during the early absorption period, but a similar amount of digoxin was found in 24 h urine whether given with or without guar gum. Both the peak penicillin concentration and the area under the serum curve were significantly reduced by the gum.
在一项针对10名健康志愿者的双盲研究中，研究了瓜尔胶对地高辛和苯氧甲基青霉素吸收的影响。瓜尔胶在吸收早期降低了血清地高辛浓度，但无论是否与瓜尔胶一起给药，24小时尿液中发现的地高辛量相似。瓜尔胶显著降低了青霉素的峰值浓度和血清曲线下面积。
