Bakke A, Göthlin J H, Haukaas S A, Kalland T
Cancer Res. 1982 Sep;42(9):3880-3.
Preoperative embolization of the renal artery has been reported to improve the survival of patients with advanced renal carcinomas compared to operative treatment only. To investigate possible immunological consequences of tumor embolization, natural killer (NK) cell activity in peripheral blood was investigated immediately before and at different time intervals after occlusion of the renal artery by insertion of a metal coil. A slight increase in NK activity could be observed 24 hr postembolization while a marked augmentation was seen after 48 hr. The high NK activity persisted up to 96 hr after embolization, the last time period included in the study. Two patients undergoing the same procedure but in whom embolization was unsuccessful showed no alteration in NK activity. It is suggested that interferon produced by macrophages activated by the necrotizing tumor might be responsible for the augmentation of NK activity.
据报道，与仅进行手术治疗相比，术前对肾动脉进行栓塞可提高晚期肾癌患者的生存率。为了研究肿瘤栓塞可能产生的免疫后果，在通过插入金属线圈闭塞肾动脉之前及之后的不同时间间隔，对外周血中的自然杀伤（NK）细胞活性进行了研究。栓塞后24小时可观察到NK活性略有增加，而48小时后则出现显著增强。栓塞后高NK活性持续至96小时，这是该研究涵盖的最后一个时间段。两名接受相同手术但栓塞未成功的患者，其NK活性没有变化。有人提出，由坏死肿瘤激活的巨噬细胞产生的干扰素可能是NK活性增强的原因。
