Senapati N, Houchens D, Ovejera A, Beard R, Nines R
Cancer Treat Rep. 1982 Aug;66(8):1635-9.
Ultrasonic energy can generate controlled, local hyperthermia (42 degrees C--43 degrees C), and ultrasonic hyperthermia results in increased cytotoxicity of chemotherapeutic drugs for the treatment of cancer. Human breast (MX-1) and lung (LX-1) tumors implanted subcutaneously in athymic nude mice were treated with a single application of ultrasonic (670 kHz, peak intensity of 5 watts/cm2) hyperthermia (43.0 degrees C +/- 0.5 degrees C) for 30 minutes in combination with suboptimal doses of cyclophosphamide, melphalan, or procarbazine. Delays in the tumor growth rate and temporary tumor regression were observed. Comparison of the tumor growth rate with single modalities, ie, drug or hyperthermia alone, shows evidence of synergistic effects of the combination of ultrasonic hyperthermia and melphalan on MX-1 and of hyperthermia and procarbazine on LX-1 tumors.
超声能量可产生可控的局部热疗（42摄氏度至43摄氏度），超声热疗可增强化疗药物对癌症治疗的细胞毒性。将人乳腺（MX - 1）和肺（LX - 1）肿瘤皮下植入无胸腺裸鼠体内，单次应用超声（670千赫兹，峰值强度5瓦/平方厘米）热疗（43.0摄氏度±0.5摄氏度）30分钟，并联合使用次优剂量的环磷酰胺、美法仑或丙卡巴肼进行治疗。观察到肿瘤生长速率延迟和肿瘤暂时消退。将该联合治疗与单一治疗方式（即单独使用药物或热疗）的肿瘤生长速率进行比较，结果表明超声热疗与美法仑联合对MX - 1肿瘤、热疗与丙卡巴肼联合对LX - 1肿瘤具有协同作用。
