Haworth S G, Hislop A A
Cardiovasc Res. 1982 Jun;16(6):293-303. doi: 10.1093/cvr/16.6.293.
Pigs were exposed to hypoxia for 2 to 5 days, at ages ranging from bith to 2 weeks. The effect of hypoxia on structural adaptation of the pulmonary arterial circulation to extra-uterine life was studied by applying quantitative morphometric techniques to the injected autopsy lung specimens. In animals exposed to hypoxia from birth, the reduction in arterial muscularity, and increase in size and number which normally takes place after, began to occur, but the process was arrested by exposure to hypoxia which with increase in exposure time caused a secondary increase in muscularity. In animals allowed to adapt fully to extra-uterine life and first exposed at 14 days, increase in muscularity as shown by an increase in wall thickness and extension of muscle into smaller and more peripheral arteries than is normal, was secondary to the hypoxic insult and similar to that reported in adults of other species. Animals exposed a between 2 and 7 days of age showed an intermediate response, failure to adapt normally plus a secondary increase in muscularity. Right ventricular hypertrophy developed in all animals. The studies emphasise the vulnerability of the newborn pulmonary circulation to hypoxia and the rapidity with which structural change occurs.
将出生至2周龄的猪暴露于低氧环境2至5天。通过对注入的尸检肺标本应用定量形态测量技术，研究低氧对肺动脉循环结构适应宫外生活的影响。在出生时即暴露于低氧环境的动物中，通常在出生后发生的动脉肌层减少以及大小和数量增加开始出现，但该过程因暴露于低氧环境而停止，随着暴露时间的增加，导致肌层继发性增加。在完全适应宫外生活且在14天时首次暴露于低氧环境的动物中，肌层增加表现为壁厚增加以及肌肉延伸至比正常情况更小且更外周的动脉，这是低氧损伤的继发结果，与其他物种成年动物中所报道的情况相似。在2至7日龄之间暴露于低氧环境的动物表现出中间反应，即未能正常适应并伴有肌层继发性增加。所有动物均出现右心室肥大。这些研究强调了新生儿肺循环对低氧的易损性以及结构变化发生的快速性。
