Wildgrube H J, Stang H, Winkler M, Mauritz G
Dtsch Med Wochenschr. 1982 Aug 20;107(33):1235-7. doi: 10.1055/s-2008-1070108.
Serum concentrations of conjugated cholic acid determined radioimmunologically were investigated for 3 hours after a test meal in 62 patients with fatty liver, 70 patients with chronic hepatitis and 30 patients with liver cirrhosis. Values were compared with results of further data from chemical pathology. Increased fasting bile acid values were found in 18% of patients with fatty liver, 13% with chronic hepatitis and in 70% with cirrhosis. Following the test meal maximum concentration increase of cholic acid conjugates was obtained after one hour. 70.5% of patients with fatty liver, 80% of patients with chronic hepatitis and 97% of patients with cirrhosis were identifiable by increased bile acid levels. Postprandial serum bile acid levels therefore have a higher sensitivity for diagnosis of liver disease than bilirubin, glutamic-oxaloacetic transaminase, alkaline phosphatase or gamma-glutamyl transferase.
采用放射免疫法测定了62例脂肪肝患者、70例慢性肝炎患者和30例肝硬化患者在试餐后3小时内的血清结合胆酸浓度。将这些值与来自化学病理学的进一步数据结果进行了比较。在脂肪肝患者中，18%的患者空腹胆汁酸值升高；慢性肝炎患者中，13%的患者空腹胆汁酸值升高；肝硬化患者中，70%的患者空腹胆汁酸值升高。试餐后1小时，胆酸结合物的浓度达到最高增加值。通过胆汁酸水平升高可识别出70.5%的脂肪肝患者、80%的慢性肝炎患者和97%的肝硬化患者。因此，餐后血清胆汁酸水平对肝病诊断的敏感性高于胆红素、谷草转氨酶、碱性磷酸酶或γ-谷氨酰转移酶。
