Hyne R V, Boettcher B
Fertil Steril. 1978 Sep;30(3):322-8. doi: 10.1016/s0015-0282(16)43520-x.
The binding of steroids to human ejaculated spermatozoa and the effect of steroids bound to spermatozoa on sperm migration and motility in vitro was examined. A correlation between progestogens that bind to steroid-binding sites on human spermatozoa and progestogens that inhibit sperm migration was established. The results indicated that there is a direct and specific steroid effect on human spermatozoa, as some steroids such as progesterone, lynestrenol, and norethynodrel markedly inhibited sperm migration and motility, whereas other steroids such as estrone had no detectable effect on sperm migration and motility. The significance of these findings was discussed in relation to the contraceptive action of steroids applied directly to the lumen of the female genital tract.
研究了类固醇与人类射出精子的结合以及结合在精子上的类固醇对精子体外迁移和活力的影响。确定了与人类精子上类固醇结合位点结合的孕激素和抑制精子迁移的孕激素之间的相关性。结果表明，类固醇对人类精子有直接且特异性的作用，因为某些类固醇如孕酮、炔雌醇和异炔诺酮显著抑制精子迁移和活力，而其他类固醇如雌酮对精子迁移和活力没有可检测到的影响。结合直接应用于女性生殖道管腔的类固醇的避孕作用讨论了这些发现的意义。
