Trifunac N P, Bernstein G S
Contraception. 1981 May;23(5):527-41. doi: 10.1016/0010-7824(81)90080-9.
Information relating to the effect of steroids on the metabolism and motility of human spermatozoa is limited despite the increasing interest in the use of these hormones for the purpose of contraception. In the present study it was shown that progesterone, testosterone, and 11-beta-OH-progesterone significantly inhibit the CO2 production of human spermatozoa. Estrone was ineffective. Progesterone and testosterone, but not estrone, also significantly depressed O2 uptake. In contrast to CO2 production and O2 uptake, lactic acid production was not significantly affected by any of the steroids studied. The inability of estrone to inhibit sperm metabolism was not due to its lower solubility relative to the other steroids tested. The data indicate that the effective steroids inhibit sperm respiration, but not the sperm glycolytic pathway.
尽管人们对使用这些激素进行避孕的兴趣日益浓厚，但关于类固醇对人类精子代谢和活力影响的信息仍然有限。在本研究中，已表明孕酮、睾酮和11-β-羟基孕酮可显著抑制人类精子的二氧化碳产生。雌酮则无效。孕酮和睾酮，但不包括雌酮，也显著降低了氧气摄取。与二氧化碳产生和氧气摄取相反，乳酸产生不受所研究的任何一种类固醇的显著影响。雌酮无法抑制精子代谢并非因其相对于其他测试类固醇的溶解度较低。数据表明，有效的类固醇抑制精子呼吸，但不抑制精子糖酵解途径。
