1,2-二溴-3-氯丙烷对人类精子发生的抑制作用。

Suppressive effect of 1,2-dibromo-3-chloropropane on human spermatogenesis.

作者信息

Potashnik G, Ben-Aderet N, Israeli R, Yanai-Inbar I, Sober I

出版信息

Fertil Steril. 1978 Oct;30(4):444-7. doi: 10.1016/s0015-0282(16)43580-6.

Abstract

Azoospermia was diagnosed in six factory workers who had been chronically exposed to 1,2-dibromo-3-chloropropane. Infertility was the presenting symptom in two patients and a decrease in libido or impotence characterized the others. Hormone studies revealed elevated plasma follicle-stimulating hormone levels and normal plasma luteinizing hormone and testosterone concentrations. Testicular biopsy showed selective atrophy of the germinal epithelium, intact Sertoli cells, and a normal appearance of a relatively increased number of Leydig cells.

摘要

六名长期接触1,2 - 二溴 - 3 - 氯丙烷的工厂工人被诊断为无精子症。两名患者的主要症状是不育，其他患者则表现为性欲减退或阳痿。激素研究显示血浆促卵泡激素水平升高，而血浆促黄体生成素和睾酮浓度正常。睾丸活检显示生精上皮选择性萎缩，支持细胞完整，且间质细胞数量相对增加，外观正常。