[组胺和五肽胃泌素对下丘脑 - 神经垂体分泌系统功能状态的影响]
[Effect of histamine and pentagastrin on the functional state of the hypothalamo-neurohypophyseal secretory system].
作者信息
Kosenko A F, Mel'nik L A, Kushnir V E
出版信息
Fiziol Zh SSSR Im I M Sechenova. 1978 Sep;64(9):1273-7.
PMID:710632
Abstract
Histochemistry, cario- and zytometry methods showed that the activators of gastric secretion (histamine and pentagastrine) exerted opposite effects upon functional state of hypothalamo-neurohypophyseal secretory system in the guinea-pigs. Histamine (4 mg/kg) activated the system and induced the development of gastric mucosa defects. Pentagastrine (5, 12, 15, 25, and 60 mcg/kg) decreased the activity of the system. No gastric mucosa or duodenum defects developed after pentagastrine administration.
摘要
组织化学、心脏及细胞计数法显示，胃分泌激活剂（组胺和五肽胃泌素）对豚鼠下丘脑 - 神经垂体分泌系统的功能状态产生相反作用。组胺（4毫克/千克）激活该系统并导致胃黏膜缺损的出现。五肽胃泌素（5、12、15、25和60微克/千克）降低该系统的活性。给予五肽胃泌素后未出现胃黏膜或十二指肠缺损。
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