Piniewska D
Diabete Metab. 1982 Jun;8(2):109-13.
Administration of phenformin to healthy subjects in a daily dose of 150 mg for a four day period caused a significant increase of 30% in the alanine level, as well as significant increases in the branched-chain amino acids valine, isoleucine, and a selective lowering in the level of arginine. Dexamethasone administered to healthy subjects in a daily dose of 3 mg over a four day period caused significant increases in alanine and methionine levels (26%) as well as a rise in arginine. Simultaneous administration of phenformin and dexamethasone resulted in significant changes in levels of glutamine, alanine, methionine and isoleucine. The highest rise (55%) was observed in alanine and methionine rose by 34%. The level of arginine decreased by 13% and glutamic acid by 39%. The fasting levels of plasma free amino acids in diabetics were similar to those in healthy subjects. The changes in the levels of plasma free amino acids after phenformin were also similar. The observed results support the suggestion that phenformin inhibits gluconeogenesis.
给健康受试者每日服用150毫克苯乙双胍，持续四天，导致丙氨酸水平显著升高30%，同时支链氨基酸缬氨酸、异亮氨酸也显著增加，精氨酸水平选择性降低。给健康受试者每日服用3毫克地塞米松，持续四天，导致丙氨酸和蛋氨酸水平显著升高（26%），精氨酸水平也升高。同时服用苯乙双胍和地塞米松导致谷氨酰胺、丙氨酸、蛋氨酸和异亮氨酸水平发生显著变化。丙氨酸升高幅度最大（55%），蛋氨酸升高34%。精氨酸水平下降13%，谷氨酸水平下降39%。糖尿病患者空腹血浆游离氨基酸水平与健康受试者相似。服用苯乙双胍后血浆游离氨基酸水平的变化也相似。观察结果支持苯乙双胍抑制糖异生的观点。
