胆汁酸对人结肠体外运动功能的影响。
Effects of bile acids on human colonic motor function in vitro.
作者信息
Flynn M, Hammond P, Darby C, Taylor I
出版信息
Digestion. 1982;23(3):211-6. doi: 10.1159/000198729.
The effect of bile acid perfusion on colonic motor function in vitro has been studied. It was found that bile acid perfusion and carbachol perfusion had no effect on the frequency or incidence of slow wave activity. However, the secondary bile acid deoxycholic acid (15 mmol/l) was shown to cause a statistically significant increase in percentage motility of the isolated colon (control 24.2 + 5.5%, deoxycholic acid 64.9 + 7.3%, p less than 0.01). The magnitude of this increase was similar to the increased colonic motility recorded during carbachol (2.5 micrograms/cm3) infusion. Chenodeoxycholic and cholic acids did not increase colonic motility in vitro.
已经研究了胆汁酸灌注对体外结肠运动功能的影响。发现胆汁酸灌注和卡巴胆碱灌注对慢波活动的频率或发生率没有影响。然而，继发性胆汁酸脱氧胆酸（15毫摩尔/升）显示可使离体结肠的运动百分比有统计学意义的增加（对照组24.2 + 5.5%，脱氧胆酸64.9 + 7.3%，p小于0.01）。这种增加的幅度与卡巴胆碱（2.5微克/立方厘米）输注期间记录到的结肠运动增加相似。鹅脱氧胆酸和胆酸在体外不会增加结肠运动。
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