胆汁酸灌注对肠易激综合征患者结肠运动功能的影响。
Effect of bile acid perfusion on colonic motor function in patients with the irritable colon syndrome.
作者信息
Taylor I, Basu P, Hammond P, Darby C, Flynn M
出版信息
Gut. 1980 Oct;21(10):843-7. doi: 10.1136/gut.21.10.843.
A study was performed to determine the effect of bile acid perfusion on motility in the sigmoid colon of patients with the irritable colon syndrome compared with normal subjects. Deoxycholic acid (15 mM) statistically significantly increased motility in normal subjects (control 25.0 +/- 6.4%, perfusion 71.4 +/- 7.2%, P < 0.05) but neither chenodeoxycholic acid nor cholic acid had any apparent effect. In patients with the irritable colon syndrome, however, deoxycholic acid at 5 mM concentration (control 29.8 +/- 4.2%, during perfusion 57.4 +/- 6.5%, P < 0.05) as well as at 15 mM concentration (control 19.4 +/- 5.7+, perfusion 57.8 +/- 9.6%, P < 0.05) statistically significantly increased rectosigmoid motility. Patients with the irritable colon syndrome had a high resting 0.033-0.066 Hz (2-4 c/m) electrical activity, whereas in normal subjects 0.1-0.15 Hz (6-9 c/m) activity was greater. However, there was no statistically significant alteration in either electrical rhythm during the period of bile acid perfusion. In conclusion, additional evidence is presented to suggest that deoxycholic acid is the only bile acid likely to be implicated in the motor disorder of the irritable colon syndrome.
一项研究旨在确定与正常受试者相比，胆汁酸灌注对肠易激综合征患者乙状结肠运动的影响。脱氧胆酸（15 mM）在正常受试者中显著增加了运动性（对照组25.0±6.4%，灌注组71.4±7.2%，P<0.05），但鹅去氧胆酸和胆酸均无明显作用。然而，在肠易激综合征患者中，5 mM浓度的脱氧胆酸（对照组29.8±4.2%，灌注期间57.4±6.5%，P<0.05）以及15 mM浓度的脱氧胆酸（对照组19.4±5.7+，灌注组57.8±9.6%，P<0.05）均显著增加了直肠乙状结肠的运动性。肠易激综合征患者静息时的电活动频率为0.033 - 0.066 Hz（2 - 4次/分钟），而正常受试者0.1 - 0.15 Hz（6 - 9次/分钟）的活动更强。然而，在胆汁酸灌注期间，电节律均无统计学上的显著改变。总之，有更多证据表明脱氧胆酸是唯一可能与肠易激综合征运动障碍有关的胆汁酸。
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