Harada H, Ueda O, Yasuoka M, Nakamura T, Hayashi T, Kobayashi T, Kimura I
Gastroenterol Jpn. 1982 Apr;17(2):98-101. doi: 10.1007/BF02774547.
The previous histochemical study on the endoscopically obtained protein plugs revealed the process of protein plug formation. The present scanning electron-microscopic study was performed to clarify the fine structure of the protein plug and was quite in accordance with the results of the histochemical study: (1) protein plugs were constructed of interlacing networks and amorphous material stuffed in the networks; (2) protein plug formation started in the form of random and loose interlacing of cottony network fibrils and poor stuffing with degenerating epithelial cells and amorphous material, and in this stage protein plugs enlarged by adherence of smaller aggregates; (3) with maturation, protein plugs came to be covered by stratiform fine net works which were more compactly built up with uniformly thick, dense and smooth fibers and were stuffed more densely with amorphous material; (4) mature protein plugs were considered to enlarge by repeated process of stratiform deposit of reticular substance and amorphous material and subsequent maturation. However, it remains to be clarified which factors induce the changes of networks from random interlacing to stratiform arrangement.
先前对通过内镜获取的蛋白栓进行的组织化学研究揭示了蛋白栓的形成过程。进行本次扫描电子显微镜研究是为了阐明蛋白栓的精细结构，其结果与组织化学研究结果完全相符：（1）蛋白栓由交错网络和填充在网络中的无定形物质构成；（2）蛋白栓形成始于棉絮状网络纤维随机且松散地交错，以及退化的上皮细胞和无定形物质填充较少的阶段，在此阶段蛋白栓通过较小聚集体的黏附而增大；（3）随着成熟，蛋白栓开始被层状精细网络覆盖，这些网络由均匀粗细、致密且光滑的纤维更紧密地构建而成，并填充有更密集的无定形物质；（4）成熟的蛋白栓被认为是通过网状物质和无定形物质的层状沉积以及随后的成熟这一重复过程而增大。然而，尚有待阐明是哪些因素导致网络从随机交错变为层状排列。
