染色体内基因转换与重复基因间序列同质性的维持。
Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes.
作者信息
Nagylaki T, Petes T D
出版信息
Genetics. 1982 Feb;100(2):315-37. doi: 10.1093/genetics/100.2.315.
Abstract
Intrachromosomal gene conversion is the non-reciprocal transfer of information between a pair of repeated genes on a single chromosome. This process produces eventual sequence homogeneity within a family of repeated genes. An evolutionary model for a single chromosome lineage was formulated and analyzed. Expressions were derived for the fixation probability, mean time to fixation or loss, and mean conditional fixation time for a variant repeat with an arbitrary initial frequency. It was shown that a small conversional advantage or disadvantage for the variant repeat (higher or lower probability of producing two variant genes by conversion than two wild-type genes) can have a dramatic effect on the probability of fixation. The results imply that intrachromosomal gene conversion can act sufficiently rapidly to be an important mechanism for maintaining sequence homogeneity among repeated genes.
摘要
染色体内基因转换是指在单条染色体上一对重复基因之间进行的非相互信息转移。这一过程最终会使重复基因家族内的序列趋于一致。我们构建并分析了一个单条染色体谱系的进化模型。推导出了具有任意初始频率的变异重复序列的固定概率、固定或丢失的平均时间以及平均条件固定时间的表达式。结果表明，变异重复序列的微小转换优势或劣势（通过转换产生两个变异基因的概率高于或低于产生两个野生型基因的概率）会对固定概率产生显著影响。这些结果表明，染色体内基因转换能够足够迅速地发挥作用，成为维持重复基因间序列一致性的重要机制。
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本文引用的文献
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