Langford H G
Hypertension. 1982 Sep-Oct;4(5 Pt 2):III166-9. doi: 10.1161/01.hyp.4.5_pt_2.iii166.
Antihypertensive drug treatment has been shown to be efficacious in reducing mortality, morbidity, and end-organ damage from hypertension. However, the health care consequences of providing continued antihypertensive therapy for approximately one-fourth of the adult population has led to inquiry into the potential of nutritional change as an alternative therapy. The relapse rate for the return of hypertension after withdrawal of antihypertensive drugs is greater in the obese than in the nonobese patient. The relapse rate is also much greater if the hypertension was severe before antihypertensive drugs were started. A programmed course of dietary instruction enabled participants to drop sodium excretion by 50%, and to lose approximately 5% of body weight in 32 weeks. Adequate large-scale trials to determine the therapeutic success rate of dietary modification in mild hypertension have yet to be done. Studies have been initiated in the United States and Finland to determine the feasibility of dietary modifications as a means of preventing the occurrence of hypertension. This endeavor deserves the highest priority, for the magnitude of the problem threatens to overwhelm conventional means of provision of medical care.
抗高血压药物治疗已被证明在降低高血压导致的死亡率、发病率和终末器官损害方面是有效的。然而，为大约四分之一的成年人口提供持续抗高血压治疗对医疗保健产生的影响，引发了对营养改变作为替代疗法潜力的探究。停用抗高血压药物后高血压复发率在肥胖患者中高于非肥胖患者。如果在开始使用抗高血压药物之前高血压病情严重，复发率也会高得多。一个有计划的饮食指导课程使参与者能够在32周内将钠排泄量降低50%，并减轻约5%的体重。尚未进行足够的大规模试验来确定饮食调整对轻度高血压的治疗成功率。美国和芬兰已启动研究，以确定饮食调整作为预防高血压发生手段的可行性。这项工作应被置于最优先的地位，因为该问题的严重程度可能会使传统医疗保健手段不堪重负。
