在携带艾氏腹水瘤的小鼠中进行病毒接种：抗原产生与肿瘤消退
Virus inoculation in mice bearing Ehrlich ascitic tumors: antigen production and tumor regression.
作者信息
Mettler N E, Clarke D H, Casals J
出版信息
Infect Immun. 1982 Jul;37(1):23-7. doi: 10.1128/iai.37.1.23-27.1982.
Ehrlich ascitic carcinoma, as developed in albino mice, has been used as a source of hemagglutinating and complement-fixing antigens, and it proved to be suitable for one type of antigen, or both, for at least 12 viruses of 16 tested. Hemagglutinins were obtained with members of arbovirus groups A, B, and C; complement-fixing antigens were obtained for at least one member of each antigenic group tested. Ehrlich ascitic tumor was compared with sarcoma 180 as a source of antigens; although sarcoma 180 showed many advantages over Ehrlich tumor, the latter gave, in general, better results for complement-fixing antigens. Oncolytic effect with complete recovery of the mice was observed in some instances. The highest recovery rate resulted with Congo and UNA viruses (40%), and the second highest rate resulted with dengue 2, St. Louis, Hazara, and Uukuniemi viruses (20%). The best survival was observed, in decreasing order, with Congo, St. Louis, dengue 2, Tacaribe, Sindbis, Junin, and Amapari viruses.
在白化小鼠体内产生的艾氏腹水癌已被用作血凝和补体结合抗原的来源，并且已证明它适用于至少16种测试病毒中的12种病毒的一种抗原或两种抗原。从A、B和C组虫媒病毒成员中获得了血凝素；针对所测试的每个抗原组的至少一个成员获得了补体结合抗原。将艾氏腹水瘤与肉瘤180作为抗原来源进行了比较；尽管肉瘤180相对于艾氏瘤显示出许多优势，但总体而言，后者在补体结合抗原方面产生了更好的结果。在某些情况下观察到了溶瘤作用且小鼠完全恢复。刚果病毒和UNA病毒的恢复率最高（40%），登革热2型、圣路易斯病毒、哈扎拉病毒和乌昆耶米病毒的恢复率次之（20%）。观察到的最佳存活率依次为刚果病毒、圣路易斯病毒、登革热2型、塔卡里贝病毒、辛德毕斯病毒、胡宁病毒和阿马帕里病毒。
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