人外周血单核细胞亚群分泌前列腺素E2
Prostaglandin E2 secretion by subsets of human peripheral blood monocytes.
作者信息
Treves A J, Ligumski M, Fuks Z, Haimovitz A, Rachmilewitz D
出版信息
Immunopharmacology. 1982 Jun;4(3):267-76. doi: 10.1016/0162-3109(82)90008-x.
The present study describes the secretion of prostaglandin E2 (PGE2) by various fractions of human peripheral blood monocytes, differing in their plastic adherence properties. PGE2 was found to be secreted only by phagocytic cells. Complete removal of the phagocytic monocytes, but no repeated adsorptions to a plastic surface, resulted in the abrogation of detectable PGE2 secretion. The monocyte population secreting PGE2 consisted of cells with different affinities to plastic surface. The loosely adherent phagocytic cells secreted more PGE2 than the strongly adherent phagocytic cells. The possible existence of monocyte subsets in human peripheral blood differing in their adherence property and PGE2 secretion is suggested.
本研究描述了人外周血单核细胞不同组分分泌前列腺素E2（PGE2）的情况，这些组分在塑料黏附特性上存在差异。发现只有吞噬细胞能分泌PGE2。完全去除吞噬性单核细胞，但不进行反复吸附到塑料表面的操作，会导致可检测到的PGE2分泌消失。分泌PGE2的单核细胞群体由对塑料表面具有不同亲和力的细胞组成。松散黏附的吞噬细胞比紧密黏附的吞噬细胞分泌更多的PGE2。提示人外周血中可能存在黏附特性和PGE2分泌不同的单核细胞亚群。
Zotero 插件