移植到裸鼠体内的所有人黑色素瘤的放射敏感性：修复、再氧合与剂量分割
Radiosensitivity of Nall human melanoma transplanted into nude mice: repair, reoxygenation and dose fractionation.
作者信息
Guichard M, Malaise E P
出版信息
Int J Radiat Oncol Biol Phys. 1982 Jun;8(6):1005-10. doi: 10.1016/0360-3016(82)90169-9.
Split and fractionated gamma-rays experimental have been performed on a human melanoma transplanted into nude mice using an in vitro colony assay. Repair of potentially lethal observed after a single dose of 20 Gy was found to no longer occur when 7 daily doses of 2.5 Gy were administered. In split-dose experiments, the increase in survival level probably can not be explained by repair of sublethal damage. When a single high dose of radiation is administered a certain reoxygenation is observed; however there is no reoxygenation when low radiation doses are delivered daily.
已使用体外集落测定法对移植到裸鼠体内的人黑色素瘤进行了分割和分次伽马射线实验。当给予7次每日剂量为2.5 Gy时，发现单次给予20 Gy剂量后观察到的潜在致死性损伤的修复不再发生。在分割剂量实验中，存活水平的提高可能无法用亚致死损伤的修复来解释。当给予单次高剂量辐射时，会观察到一定程度的再氧合；然而，当每日给予低辐射剂量时，则不会出现再氧合。
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