Keegan A, Hill C, Kumar S, Phillips P, Schor A, Weiss J
J Cell Sci. 1982 Jun;55:261-76. doi: 10.1242/jcs.55.1.261.
Purified tumour angiogenesis factor (TAF) obtained from rat Walker 256 carcinoma and found to induce neovascularization in vivo was examined for its effect on endothelial cell cultures of capillary (CBEC), cow aorta (CAEC) and pig aorta (PAEC) in vitro. Treatment with TAF increased the growth of capillary but not aortic endothelial cells, and then only when the cells were growing on a native collagen substratum. These data show an important growth difference between endothelial cells, in that the ability to proliferate in response to TAF depends not only on the substratum used but also on the vascular origin of the cells.
从大鼠Walker 256癌中获得的纯化肿瘤血管生成因子（TAF），已发现其在体内可诱导新血管形成，现对其在体外对毛细血管内皮细胞（CBEC）、牛主动脉内皮细胞（CAEC）和猪主动脉内皮细胞（PAEC）培养的影响进行检测。用TAF处理可增加毛细血管内皮细胞而非主动脉内皮细胞的生长，且只有当细胞在天然胶原基质上生长时才会如此。这些数据表明内皮细胞之间存在重要的生长差异，即对TAF作出反应进行增殖的能力不仅取决于所用的基质，还取决于细胞的血管来源。
