采用离子对高效液相色谱法测定血浆和尿液中的吗啡、吗啡-3-葡萄糖醛酸苷以及（初步测定）吗啡-6-葡萄糖醛酸苷。 - Suppr

Suppr

超能文献

Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography.

作者信息

Svensson J O, Rane A, Säwe J, Sjöqvist F

出版信息

J Chromatogr. 1982 Jul 9;230(2):427-32. doi: 10.1016/s0378-4347(00)80494-6.

DOI:10.1016/s0378-4347(00)80494-6

PMID:7107787

Abstract

摘要

相似文献

Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography.采用离子对高效液相色谱法测定血浆和尿液中的吗啡、吗啡-3-葡萄糖醛酸苷以及（初步测定）吗啡-6-葡萄糖醛酸苷。

J Chromatogr. 1982 Jul 9;230(2):427-32. doi: 10.1016/s0378-4347(00)80494-6.

Determination of codeine and metabolites in plasma and urine using ion-pair high-performance liquid chromatography.采用离子对高效液相色谱法测定血浆和尿液中的可待因及其代谢物。

J Chromatogr B Biomed Appl. 1995 Dec 1;674(1):49-55. doi: 10.1016/0378-4347(95)00292-1.

High-performance liquid chromatographic determination of morphine, morphine-3-glucuronide, morphine-6-glucuronide and codeine in biological samples using multi-wavelength forward optical detection.使用多波长正向光学检测法通过高效液相色谱法测定生物样品中的吗啡、吗啡 - 3 - 葡萄糖醛酸苷、吗啡 - 6 - 葡萄糖醛酸苷和可待因。

J Chromatogr. 1991 Nov 15;571(1-2):263-70. doi: 10.1016/0378-4347(91)80454-k.

Direct determination of codeine, norcodeine, morphine and normorphine with their corresponding O-glucuronide conjugates by high-performance liquid chromatography with electrochemical detection.采用高效液相色谱-电化学检测法直接测定可待因、去甲可待因、吗啡和去甲吗啡及其相应的O-葡萄糖醛酸苷缀合物。

J Chromatogr. 1991 Oct 4;570(2):309-20. doi: 10.1016/0378-4347(91)80534-j.

On-line clean-up system of plasma sample for simultaneous determination of morphine and its metabolites in cancer patients by high-performance liquid chromatography.用于通过高效液相色谱法同时测定癌症患者体内吗啡及其代谢物的血浆样品在线净化系统。

J Pharm Sci. 1990 May;79(5):379-83. doi: 10.1002/jps.2600790503.

Determination of 6-monoacetylmorphine and morphine in plasma, whole blood and urine using high-performance liquid chromatography with electrochemical detection.使用高效液相色谱-电化学检测法测定血浆、全血和尿液中的6-单乙酰吗啡和吗啡。

J Chromatogr B Biomed Appl. 1994 Nov 18;661(2):245-53. doi: 10.1016/0378-4347(94)00345-9.

Plasma concentrations and renal clearance of morphine, morphine-3-glucuronide and morphine-6-glucuronide in cancer patients receiving morphine.接受吗啡治疗的癌症患者体内吗啡、吗啡 - 3 - 葡萄糖醛酸苷和吗啡 - 6 - 葡萄糖醛酸苷的血浆浓度及肾清除率

Clin Pharmacokinet. 1993 May;24(5):413-20. doi: 10.2165/00003088-199324050-00005.

Simple method for the determination of morphine and its active glucuronide metabolite in human plasma by high-performance liquid chromatography with electrochemical detection.高效液相色谱-电化学检测法测定人血浆中吗啡及其活性葡萄糖醛酸代谢物的简易方法。

J Chromatogr. 1991 Sep 18;570(1):191-7. doi: 10.1016/0378-4347(91)80215-x.

High-performance liquid chromatographic determination of morphine and its metabolites in plasma using diode-array detection.

J Chromatogr. 1993 May 19;615(1):164-8. doi: 10.1016/0378-4347(93)80304-m.

Simultaneous determination of morphine-6-d-glucuronide, morphine-3-d-glucuronide and morphine in human plasma and urine by ultra-performance liquid chromatography-tandem mass spectrometry: Application to M6G injection pharmacokinetic study.超高效液相色谱-串联质谱法同时测定人血浆和尿液中的吗啡-6-d-葡萄糖醛酸苷、吗啡-3-d-葡萄糖醛酸苷和吗啡：在M6G注射剂药代动力学研究中的应用

Biomed Chromatogr. 2018 Feb;32(2). doi: 10.1002/bmc.4066. Epub 2017 Sep 15.

引用本文的文献

Detection of morphine-3-sulfate and morphine-6-sulfate in human urine and plasma, and formation in liver cytosol.检测人尿液和血浆中的吗啡-3-硫酸盐和吗啡-6-硫酸盐，以及在肝胞质中的形成。

Pharmacol Res Perspect. 2014 Dec;2(6):e00071. doi: 10.1002/prp2.71. Epub 2014 Sep 1.

The effect of blood sampling site and physicochemical characteristics of drugs on bioavailability after nasal administration in the sheep model.绵羊模型中采血部位和药物理化特性对鼻腔给药后生物利用度的影响。

Pharm Res. 2003 Sep;20(9):1474-84. doi: 10.1023/a:1025722614154.

The bioavailability and pharmacokinetics of subcutaneous, nebulized and oral morphine-6-glucuronide.皮下注射、雾化吸入及口服吗啡 -6- 葡萄糖醛酸苷的生物利用度和药代动力学。

Br J Clin Pharmacol. 2002 Apr;53(4):347-54. doi: 10.1046/j.1365-2125.2002.01554.x.

Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation.吗啡在血管灌注大鼠小肠制剂中的途径依赖性代谢。

Pharm Res. 2000 Mar;17(3):291-8. doi: 10.1023/a:1007548905772.

Evaluation of a solid-phase extraction procedure for the simultaneous determination of morphine, 6-monoacetylmorphine, codeine and dihydrocodeine in plasma and whole blood by GC/MS.

Int J Legal Med. 1996;109(2):80-3. doi: 10.1007/BF01355521.

Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations.吗啡在人体内的药代动力学与代谢。肠肝循环及代谢产物对活性阿片类药物浓度的相对贡献。

Clin Pharmacokinet. 1993 Apr;24(4):344-54. doi: 10.2165/00003088-199324040-00007.

Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose.单次口服剂量后乙基吗啡的生物转化与药代动力学

Br J Clin Pharmacol. 1995 Jun;39(6):611-20. doi: 10.1111/j.1365-2125.1995.tb05720.x.

Morphine metabolism in cancer patients on increasing oral doses--no evidence for autoinduction or dose-dependence.癌症患者口服剂量增加时的吗啡代谢——无自身诱导或剂量依赖性的证据

Br J Clin Pharmacol. 1983 Jul;16(1):85-93. doi: 10.1111/j.1365-2125.1983.tb02148.x.

Steady-state kinetics and analgesic effect of oral morphine in cancer patients.

Eur J Clin Pharmacol. 1983;24(4):537-42. doi: 10.1007/BF00609900.

Oral morphine in cancer patients: in vivo kinetics and in vitro hepatic glucuronidation.癌症患者口服吗啡：体内动力学与体外肝脏葡萄糖醛酸化

Br J Clin Pharmacol. 1985 Apr;19(4):495-501. doi: 10.1111/j.1365-2125.1985.tb02675.x.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验