Kleinbaum J, Shamoon H
J Clin Endocrinol Metab. 1982 Oct;55(4):787-90. doi: 10.1210/jcem-55-4-787.
The plasma response of various counterregulatory hormones was measured after an oral glucose tolerance test in 19 normal subjects. Significant elevations in plasma epinephrine (P less than 0.05) and human GH (P less than 0.05) were observed late in the course of the oral glucose tolerance test coincident with the fall in plasma glucose. Plasma norepinephrine, glucagon, and cortisol levels did not change during the latter phase of the test. The elevations in plasma human GH and epinephrine levels were unrelated to either absolute hypoglycemia or to clinical symptoms of hypoglycemia. These data suggest a possible role for adrenergic mechanisms in glucose counterregulation under physiological conditions.
在19名正常受试者口服葡萄糖耐量试验后，测量了各种对抗调节激素的血浆反应。在口服葡萄糖耐量试验后期，随着血浆葡萄糖水平下降，观察到血浆肾上腺素（P<0.05）和人生长激素（P<0.05）显著升高。在试验后期，血浆去甲肾上腺素、胰高血糖素和皮质醇水平未发生变化。血浆人生长激素和肾上腺素水平的升高与绝对低血糖或低血糖临床症状均无关。这些数据表明，在生理条件下，肾上腺素能机制在葡萄糖对抗调节中可能发挥作用。
