Courtney K D, Andrews J E, Grady M
J Environ Sci Health B. 1982;17(4):381-91. doi: 10.1080/03601238209372328.
ECh administered intragastrically to pregnant CD-1 mice from the 6th to the 16th day of gestation at a dose of 100 mg/kg produced a significant reduction in maternal weight gain and a decrease in fetal body weight and liver weight. A lower dose of 50 mg/kg had no consistent effect and a higher dose of 150 mg/kg was maternally lethal. Administration of ECh in the drinking water at doses of 16, 43, 77, or 227 mg/kg did not produce any adverse effects on maternal or fetal body weight, viability, or fetal anatomical development.
在妊娠第6天至第16天，以100毫克/千克的剂量对怀孕的CD-1小鼠进行胃内给予埃奇霉素，可显著降低母体体重增加，并使胎儿体重和肝脏重量下降。50毫克/千克的较低剂量没有一致的效果，而150毫克/千克的较高剂量对母体具有致死性。以16、43、77或227毫克/千克的剂量通过饮用水给予埃奇霉素，对母体或胎儿体重、活力或胎儿解剖发育均未产生任何不良影响。
