Wallis G P, Tabachnick W J
J Hered. 1982 Jul-Aug;73(4):291-4. doi: 10.1093/oxfordjournals.jhered.a109642.
A previously unmapped isocitrate dehydrogenase (DH) locus has been mapped on chromosome 1 in Aedes aedes aegypti. No recombination between this and sex was observed in any of the several hundred instances where crossing over could have been detected. Within an isofemale line from Daker, two ldh-1 alleles are in linkage disequilibrium with two lethal loci. The two lethals complement one another, and show no recombination with sex or ldh-1. Recombination between bz and ldh-1 was demonstrated, placing ldh-1 very close to Me and sw. The results show that in two natural populations, ldh-1 and sex are in linkage disequilibrium with each other and most probably with the two lethal loci also. The distribution of ldh-1 variation world-wide and the implications of sex-linked lethals are discussed.
一个先前未定位的异柠檬酸脱氢酶（DH）基因座已被定位在埃及伊蚊的1号染色体上。在几百个可能检测到交叉的实例中，未观察到该基因座与性别之间发生重组。在来自达喀尔的一个同雌系中，两个乳酸脱氢酶-1（ldh-1）等位基因与两个致死基因座处于连锁不平衡状态。这两个致死基因相互互补，且与性别或ldh-1均未发生重组。已证明bz与ldh-1之间发生了重组，这使得ldh-1非常靠近Me和sw。结果表明，在两个自然种群中，ldh-1与性别之间处于连锁不平衡状态，并且很可能也与两个致死基因座处于连锁不平衡状态。本文讨论了ldh-1变异在全球的分布以及性连锁致死基因的影响。
