与皮肤癌易感性相关的表皮特征。

Epidermal characteristics related to skin cancer susceptibility.

作者信息

Gregg K, Mansbridge J

出版信息

J Invest Dermatol. 1982 Sep;79(3):178-82. doi: 10.1111/1523-1747.ep12500051.

Abstract

We have compared the basal cell labeling index and cellular architecture in samples of epidermis removed by vacuum blistering from people with or without a personal history of skin cancer. Donors with no family history of skin cancer showed a basal cell labeling index of 5.5% with a standard deviation of 1.3%. Those not personally affected but with a family history gave 4.1% +/- 0.4% but among cancer patients the value was approximately doubled to 11.5% +/- 2.7%. The proportion of cells replicating was reduced after ultraviolet irradiation, with a D0 of 40 J/m2 for UVB but no difference could be demonstrated between individuals with or without a history of skin cancer.

摘要

我们比较了通过真空水疱法从有或无皮肤癌个人病史的人群中获取的表皮样本的基底细胞标记指数和细胞结构。无皮肤癌家族史的供体显示基底细胞标记指数为5.5%，标准差为1.3%。无个人皮肤癌病史但有家族史的供体该指数为4.1%±0.4%，但在癌症患者中该值约翻倍至11.5%±2.7%。紫外线照射后细胞复制比例降低，UVB的D0为40 J/m2，但有或无皮肤癌病史的个体之间未显示出差异。