Binder H J, Dobbins J W, Racusen L C, Whiting D S
Gastroenterology. 1978 Oct;75(4):668-73.
Hydroxy fatty acids and bile acids produce both intestinal fluid and electrolyte accumulation and increases in inulin clearance, a parameter of mucosal permeability. The relationship of the changes in mucosal permeability to the production of fluid and electrolyte accumulation is uncertain. These experiments were designed to determine whether the alterations of mucosal permeability produced by ricinoleic acid and deoxycholic acid were related to production of hydroxy fatty acid- and bile acid-induced fluid and electrolyte accumulation in the rat colon. Propranolol (1 mg per 100 g of body weight) administered daily for 3 days inhibited ricinoleic acid- and deoxycholic acid-induced Na and water accumulation. In contrast, propranolol did not affect either the increase in inulin clearance or the decrease in electrical potential difference produced by ricinoleic acid and deoxycholic acid. Further, amphotericin B increased inulin clearance by the colon and also increased water and Na absorption. These studies suggest that changes in mucosal permeability are not primarily responsible for hydroxy fatty acid- and bile acid-induced fluid and Na accumulation.
羟基脂肪酸和胆汁酸会导致肠液和电解质蓄积，并使菊粉清除率升高，菊粉清除率是黏膜通透性的一个指标。黏膜通透性变化与液体和电解质蓄积产生之间的关系尚不确定。这些实验旨在确定蓖麻油酸和脱氧胆酸引起的黏膜通透性改变是否与大鼠结肠中羟基脂肪酸和胆汁酸诱导的液体和电解质蓄积产生有关。连续3天每天给予普萘洛尔（每100克体重1毫克）可抑制蓖麻油酸和脱氧胆酸诱导的钠和水蓄积。相比之下，普萘洛尔既不影响蓖麻油酸和脱氧胆酸引起的菊粉清除率升高，也不影响其导致的跨膜电位差降低。此外，两性霉素B可增加结肠的菊粉清除率，还能增加水和钠的吸收。这些研究表明，黏膜通透性变化并非羟基脂肪酸和胆汁酸诱导的液体和钠蓄积的主要原因。
