Brown B D, Ammon H V
Dig Dis Sci. 1981 Aug;26(8):710-7. doi: 10.1007/BF01316860.
Jejunal perfusion studies were performed in 12 healthy volunteers to study the effects of 14 and 56 mM glucose on fluid secretion induced by 5 mM glycodeoxycholate on 7 mM oleate. Glucose enhanced water absorption under control conditions and reduced water secretion induced by glycodeoxycholate or oleate (P less than 0.01). As has been observed previously, glycodeoxycholate and oleate inhibited glucose absorption (P less than 0.001) and significant linear relationships existed between net water movement and glucose absorption. Glycodeoxycholate also reduced the absorption of 14 mM arabinose (P less than 0.05) and oleate reduced the absorption of 56 mM mannitol (P less than 0.05). Reduced solute absorption in the presence of glycodeoxycholate and oleate, therefore, cannot be attributed to an effect on active transport alone. The relationships between sodium transport and water absorption varied with the glucose concentration in the perfusion solutions. Similarly, the relationships between glucose absorption and sodium absorption varied with glucose concentration. The data suggest that a significant amount of glucose can be absorbed without concomitant absorption of sodium. The data indicate that glucose absorption can stimulate water absorption directly without the mediation of sodium and that water movement follows glucose at a rate which maintains isotonicity.
对12名健康志愿者进行空肠灌注研究，以探讨14 mM和56 mM葡萄糖对5 mM甘氨脱氧胆酸盐联合7 mM油酸诱导的液体分泌的影响。在对照条件下，葡萄糖增强了水的吸收，并减少了由甘氨脱氧胆酸盐或油酸诱导的水分泌（P<0.01）。如先前观察到的，甘氨脱氧胆酸盐和油酸抑制葡萄糖吸收（P<0.001），并且净水移动与葡萄糖吸收之间存在显著的线性关系。甘氨脱氧胆酸盐还降低了14 mM阿拉伯糖的吸收（P<0.05），油酸降低了56 mM甘露醇的吸收（P<0.05）。因此，在存在甘氨脱氧胆酸盐和油酸的情况下溶质吸收减少不能仅归因于对主动转运的影响。钠转运与水吸收之间的关系随灌注溶液中葡萄糖浓度的变化而变化。同样，葡萄糖吸收与钠吸收之间的关系也随葡萄糖浓度而变化。数据表明，大量葡萄糖可以在不伴随钠吸收的情况下被吸收。数据表明，葡萄糖吸收可直接刺激水吸收，而无需钠的介导，并且水的移动以维持等渗性的速率跟随葡萄糖。
