未麻醉大鼠脉络丛血流和葡萄糖利用的放射自显影评估。

Autoradiographic assessment of choroid plexus blood flow and glucose utilization in the unanesthetized rat.

作者信息

Tyson G, Kelly P, McCulloch J, Teasdale G

出版信息

J Neurosurg. 1982 Oct;57(4):543-7. doi: 10.3171/jns.1982.57.4.0543.

DOI:10.3171/jns.1982.57.4.0543

Abstract

Choroid plexus blood flow (CPBF) and glucose utilization (CPGU) were measured in two groups, each of seven identically prepared, unanesthetized rats, using complementary quantitative autoradiographic techniques. Both CPBF and CPGU were lowest in the lateral ventricles (0.83 +/- 0.01 . g-1 . min-1 and 0.70 +/- 0.02 mumoles . g-1 . min-1, respectively) and highest in the fourth ventricle (1.56 +/- 0.05 ml l g-1 . min-1 and 1.39 +/- 0.05 mumoles . g-1 . min-1, respectively). Despite this heterogeneity, the proportionate relationship between CPBF and CPGU was relatively constant throughout the ventricular system. This suggests that blood flow and metabolism may normally be coupled in the choroid plexus, and that the choroid plexus of the fourth ventricle may account for a disproportionate share of the functional activity of this tissue.

摘要

采用互补定量放射自显影技术，在两组动物中测量脉络丛血流量（CPBF）和葡萄糖利用率（CPGU），每组有7只经相同处理的未麻醉大鼠。侧脑室中的CPBF和CPGU均最低（分别为0.83±0.01 ml·g-1·min-1和0.70±0.02 μmol·g-1·min-1），第四脑室中的最高（分别为1.56±0.05 ml·g-1·min-1和1.39±0.05 μmol·g-1·min-1）。尽管存在这种异质性，但在整个脑室系统中，CPBF与CPGU之间的比例关系相对恒定。这表明，正常情况下脉络丛中的血流与代谢可能是耦合的，并且第四脑室的脉络丛可能在该组织的功能活动中占不成比例的份额。