Chervu S, Chervu L R, Goodwin P N, Blaufox M D
J Nucl Med. 1982 Aug;23(8):667-70.
The measurement of radioiodine uptake is generally considered to be straight-forward and accurate. However, during the past two decades, discrepancies in "normal" thyroid uptake values have been noticed between Montefiore Hospital and Medical Center and the Hospital of Albert Einstein College of Medicine. These differences were attributed to differences in patient population. Further investigation revealed that the persisting uptake discrepancies arose from neck-phantom differences and variations in procedure. Differences in presumably standardized neck-phantom attenuation characteristics have been shown to cause large variations in count rates from I-123 and I-131 standard capsules. The effect of high-voltage fluctuation on phantom count rates is more pronounced with I-123 than with I-131. In constant levels of high-energy contaminants in I-123 also affect the uptake measurements. large errors in the measurements of thyroid uptake values may result from seemingly unimportant variations in technique. A stable high-voltage power supply, precise high-voltage adjustment, careful selection of energy window, and the use of a standardized neck phantom with generally accepted attenuation characteristics are absolutely essential if RAIU values are to be compared and appropriate therapeutic doses are to be administered based on these measurements.
放射性碘摄取的测量通常被认为是直接且准确的。然而，在过去二十年中，蒙特菲奥里医院和医疗中心与阿尔伯特·爱因斯坦医学院医院之间的“正常”甲状腺摄取值存在差异。这些差异归因于患者群体的不同。进一步调查发现，持续存在的摄取差异源于颈部模型差异和操作变化。据推测，标准化颈部模型衰减特性的差异已被证明会导致来自 I - 123 和 I - 131 标准胶囊的计数率出现很大变化。与 I - 131 相比，I - 123 的高压波动对模型计数率的影响更为明显。I - 123 中高能污染物的恒定水平也会影响摄取测量。看似不重要的技术变化可能导致甲状腺摄取值测量中的大误差。如果要比较放射性碘摄取率（RAIU）值并基于这些测量给予适当的治疗剂量，稳定的高压电源、精确的高压调节、仔细选择能量窗以及使用具有普遍接受的衰减特性的标准化颈部模型绝对至关重要。
