Cassio A, Turba E, Balsamo A, Ballestrazzi A, Pozzato R, Marinelli M
Eur J Nucl Med. 1984;9(8):351-3. doi: 10.1007/BF00252868.
Seventeen patients, screened from a neonatal programme for hypothyroidism were studied. As well as the scintigraphic investigations, serum TSH, T3, free T3, T4, free T4, and TBG were measured in all patients. Not more than 11.1 MBq (300 microCi) 99mTcO4- was administered IV. A gamma camera with a parallel-hole collimator on line with the computer was used. The method allowed good statistics to be obtained in 5-10 min in a wide field of exploration, thus reducing the problems of positioning and prolonged immobilization of the young patient. The data collected in the computer were elaborated to define better the characteristics of the thyroid image. This kind of in vivo study introduced into a screening programme, enables an 'anatomic' diagnosis of the defect to be obtained before starting the therapy. This is undoubtedly valuable from the epidemiological point of view, enables early determination of the degree of thyroid insufficiency, and contributes to the formulation of a prognosis based on the degree and on the moment in which prenatal harm occurred.
对从新生儿甲状腺功能减退症筛查项目中筛选出的17名患者进行了研究。除了闪烁扫描检查外，还对所有患者测量了血清促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、游离三碘甲状腺原氨酸（FT3）、甲状腺素（T4）、游离甲状腺素（FT4）和甲状腺素结合球蛋白（TBG）。静脉注射不超过11.1 MBq（300微居里）的高锝酸盐（99mTcO4-）。使用一台配有平行孔准直器且与计算机联机的γ相机。该方法能在5至10分钟内在广阔的探测视野中获得良好的统计数据，从而减少了年幼患者的定位问题和长时间固定的问题。对计算机收集的数据进行了处理，以更好地界定甲状腺图像的特征。这种引入筛查项目的体内研究能够在开始治疗前对缺陷进行“解剖学”诊断。从流行病学角度来看，这无疑具有重要价值，能够早期确定甲状腺功能不全的程度，并有助于根据产前损害发生的程度和时间制定预后。
