Danielides I C, Mellow M H
Gastroenterology. 1978 Dec;75(6):1115-9.
In order to evaluate the effect of acute moderate hypercalcemia on both smooth and skeletal muscle function of the human esophagus, 12 subjects were given intravenous calcium chloride in normal saline. Serum calcium increased from a basal value of 9.6 +/- 0.1 mg per dl (mean +/- 1 SEM) to 11.4 +/- 0.2 mg per dl at 90 min after initiation of calcium infusion (P less than 0.01). Both amplitude and Dp/Dt of esophageal contractions decreased significantly in the skeletal muscle segment; however, amplitude and Dp/Dt increased significantly in the smooth muscle segment. Lower esophageal sphincter pressure remained unchanged. Duration of contractions and peristaltic wave speed were unaltered. Possible explanations for the divergent effect of hypercalcemia on the two types of esophageal muscle are discussed.
为了评估急性中度高钙血症对人体食管平滑肌和骨骼肌功能的影响，12名受试者静脉输注生理盐水溶解的氯化钙。血清钙从基础值每分升9.6±0.1毫克（平均值±1个标准误）在开始输注钙后90分钟升至每分升11.4±0.2毫克（P<0.01）。骨骼肌段食管收缩的幅度和dp/dt显著降低；然而，平滑肌段的幅度和dp/dt显著增加。食管下括约肌压力保持不变。收缩持续时间和蠕动波速度未改变。讨论了高钙血症对两种类型食管肌肉产生不同影响的可能原因。
