Fourie I J, Pauw F H, de Bruin B
J Urol. 1982 Aug;128(2):262-3. doi: 10.1016/s0022-5347(17)52879-7.
A brownish discoloration of the bladder mucosa on cystoscopy and the histological findings in a bladder biopsy specimen of submucosal vascular basement membrane thickening, pigment or chronic inflammatory changes in the absence of infection were present in various combinations in all our patients with analgesic-associated nephropathy. None of these findings was present in a control group of patients with other established causes of renal function impairment. More objective diagnostic aids may lead to a greater awareness and earlier diagnosis of this preventable cause of chronic renal failure.
在我们所有患有镇痛剂相关性肾病的患者中，膀胱镜检查时膀胱黏膜出现褐色变色，膀胱活检标本的组织学检查结果显示黏膜下血管基底膜增厚、色素沉着或慢性炎症改变（无感染），这些表现以各种组合形式出现。在其他已确定的肾功能损害原因的患者对照组中，均未出现这些表现。更客观的诊断辅助手段可能会提高对这种可预防的慢性肾衰竭病因的认识并实现早期诊断。
