Palvio D H, Falk E, Andersen J C
Virchows Arch A Pathol Anat Histopathol. 1985;408(2-3):173-82. doi: 10.1007/BF00707980.
In four cases of capillarosclerosis in the urinary tract associated with analgesic (phenacetin) abuse, the basement membrane (BM) thickening was not confined to the subepithelial capillaries, but was also found around the smooth muscle cells in the luminal part of the tunica muscularis. Electron microscopy confirmed that the changes in the BM around the smooth muscle cells were similar to those seen around capillaries. This non-vascular affection of BM in the urinary tract in patients with phenacetin abuse has not been reported previously. Thus, capillarosclerosis appears to be only part of a BM disorder, that clearly diminishes in intensity with increasing distance from the lumen. It is therefore suggested that the changes are caused by some agent (possibly a metabolite) in the urine diffusing from the lumen into the wall of the urinary tract.
在4例与滥用镇痛药（非那西丁）相关的泌尿道毛细血管硬化病例中，基底膜（BM）增厚不仅局限于上皮下毛细血管，在肌层管腔部分的平滑肌细胞周围也有发现。电子显微镜证实，平滑肌细胞周围BM的变化与毛细血管周围所见变化相似。非那西丁滥用患者泌尿道BM的这种非血管性病变以前未见报道。因此，毛细血管硬化似乎只是BM紊乱的一部分，其强度显然随着距管腔距离的增加而减弱。因此，提示这些变化是由尿液中的某种物质（可能是一种代谢产物）从管腔扩散到泌尿道壁所致。
