Gorisch W, Boergen K P
Lasers Surg Med. 1982;2(1):1-13. doi: 10.1002/lsm.1900020101.
Heat-induced spontaneous contraction of blood vessels as observed during the application of surgical lasers was investigated experimentally. By means of extravascular irrigation of veins and arteries from the rabbit mesentery in vivo with saline that had been preheated to varying temperatures in the range of 45-90 degrees C, the temperature dependence on contraction with evaluated. It was demonstrated that lower temperature thresholds of approximately 70 degrees C and 75 degrees C exist for the shrinkage of veins and arteries, respectively. Ultrastructural investigation of the walls of contracted and of noncontracted vessels indicates that vessel contraction correlates with the denaturation of collagen fibrils. It was therefore concluded that the well-known heat shrinkage effect of denatured collagen accounts for the heat-induced vessel constriction. It is shown that on heat-induced permanent occlusion, vessels of the type that were examined cannot be achieved reliably at temperatures of up to 90 degrees C for 16 sec; in most cases relaxation takes place.
对手术激光应用过程中观察到的血管热诱导自发收缩进行了实验研究。通过在体内对兔肠系膜的静脉和动脉进行血管外灌注预热至45-90摄氏度范围内不同温度的生理盐水，评估了收缩与温度的相关性。结果表明，静脉和动脉收缩的较低温度阈值分别约为70摄氏度和75摄氏度。对收缩和未收缩血管壁的超微结构研究表明，血管收缩与胶原纤维的变性相关。因此得出结论，变性胶原的众所周知的热收缩效应是热诱导血管收缩的原因。结果表明，对于所检查类型的血管，在高达90摄氏度的温度下持续16秒不能可靠地实现热诱导永久性闭塞；在大多数情况下会发生松弛。
