Colpaert F C, Meert T, De Witte P, Schmitt P
Life Sci. 1982 Jul 5;31(1):67-75. doi: 10.1016/0024-3205(82)90402-7.
The experiments described here were aimed at further validating adjuvant arthritis as an animal model of chronic pain. It was found that the relative oral intake of a 0.008 mg/ml solution of fentanyl was higher in arthritic than in normal control rats; this difference was predicted by the notion that the analgesic effect of a substance may reinforce its intake in animals exposed to pain, more so than in normal pain-free animals. It was also found that body weight decreases and that vocalizations of aggregated rats increase as a result of the challenge; these effects suggest that the vegetative signs and the behavioral irritability which are characteristic of chronic pain in humans, also occur in arthritic animals. The pain which thus seems to be associated with adjuvant arthritis was estimated to have its onset on days 10-11, to peak on days 18-21, and to terminate on days 35-40 after inoculation with Mycobacterium butyricum.
此处所描述的实验旨在进一步验证佐剂性关节炎作为慢性疼痛动物模型的有效性。研究发现，关节炎大鼠对0.008mg/ml芬太尼溶液的相对口服摄入量高于正常对照大鼠；这一差异可由以下观点解释：一种物质的镇痛作用可能会增强其在遭受疼痛的动物体内的摄入量，这种增强作用在正常无痛动物中更为明显。研究还发现，由于这种刺激，大鼠体重下降，聚集大鼠的发声增加；这些效应表明，人类慢性疼痛所特有的植物性体征和行为易怒性在患有关节炎的动物中也会出现。接种丁酸分枝杆菌后，与佐剂性关节炎相关的疼痛似乎在第10 - 11天开始，在第18 - 21天达到峰值，并在第35 - 40天结束。
