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Genetic analysis of an N-ethyl-N-nitrosourea-induced mutation at the hemoglobin beta-chain locus in mice.

作者信息

Murota T, Shibuya T, Tutikawa K

出版信息

Mutat Res. 1982 May-Jun;104(4-5):317-21. doi: 10.1016/0165-7992(82)90162-2.

DOI:10.1016/0165-7992(82)90162-2
PMID:7110170
Abstract

The specific-locus test was performed with N-ethyl-N-nitrosourea (ENU) on spermatogonia of mice by using visible loci and a hemoglobin beta-chain (Hbb) locus. Male wild-type (C3Hf/He) mice were injected intraperitoneally with ENU. 8 weeks after injection, these males were mated with tester strain females (PW). 9 visible mutants and the 1 Hbb locus mutant were obtained. This Hbb locus mutation was heritable and viable under homozygous conditions, suggesting that it might have resulted from events at the molecular level.

摘要

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引用本文的文献

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A mouse beta-globin mutant that is an exact model of hemoglobin Rainier in man.一种小鼠β-珠蛋白突变体，它是人类血红蛋白雷尼尔的精确模型。
Genetics. 1985 Aug;110(4):709-21. doi: 10.1093/genetics/110.4.709.