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通过旋转活动笼法观察动物行为:介绍一种借助旋转活动笼对小鼠运动活动进行自动测量和记录的新系统(作者译)

[Observation of animal behavior by revolving activity cage method: A new automatic measuring and recording system of motor activity of a mouse by means of revolving activity cage is presented (author's transl)].

作者信息

Nakamura K

出版信息

Nihon Yakurigaku Zasshi. 1978 Sep;74(6):671-86.

PMID:711027
Abstract

With this system, several parameters can be recorded continuously over several months without exterior stimuli. Time per revolution is counted and punched into the paper tape as binary coded numbers, and the number of revolutions and the frequency of "passage" in a given time are printed out on a rolled paper by a digital recorder. "Passage" is defined as one revolving trial without a pause over a fixed time (criterion time) and used as a behavioral unit of "stop and go". The raw data on the paper tape are processed and analyzed with a general-purpose computer. It was confirmed that when a mouse became well accustomed to the revolving activity cage, the time per revolution followed the law of exponential distribution probability, while the length of passage (i.e. the number of revolutions per revolving trial) followed that of geometrical distribution probability. The revolving activity of mice treated with single subcutaneous injection of methamphetamine was examined using these parameters.

摘要

通过这个系统,可以在没有外部刺激的情况下连续数月记录几个参数。每转一圈的时间被计数,并作为二进制编码数字打孔到纸带中,转数和给定时间内“通过”的频率由数字记录仪打印在卷纸上。“通过”被定义为在固定时间(标准时间)内无停顿的一次旋转试验,并用作“走走停停”的行为单位。纸带上的原始数据用通用计算机进行处理和分析。已证实,当小鼠很好地适应旋转活动笼时,每转一圈的时间遵循指数分布概率规律,而通过的长度(即每次旋转试验的转数)遵循几何分布概率规律。使用这些参数检查单次皮下注射甲基苯丙胺处理的小鼠的旋转活动。

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