The effect of short-term and prolonged fructose intake on VLDL-TG and relative properties on apo CIII1 and apo CII in the VLDL fraction in type IV hyperlipoproteinaemia.

Twenty two patients with hyperlipoproteinaemia type IV consumed fructose in a daily dose of 80 g for 28 days. Apart from that they kept their normal diet. We observed the considerable heterogeneity of hyperlipaemic responses of patients under study after 7 days of fructose feeding. However VLDL-TG and the relative ratio apo CIII1/apo CII in VLDL increased in the whole group. The rise in serum VLDL was associated with a fall in LDL-Chol and HDL-Chol. After extention of fructose intake to 28 days a decrease of VLDL-TG with concomitant fall of the relative ratio apo CIII1/apo CII in VLDL was found. LDL-Chol increased. Our observations point to the reversibility of fructose-induced changes in the lipoprotein composition after prolongation of its intake.