Hishida A, Honda N, Sudo M, Kimura M, Nagase M
Nephron. 1982;30(4):368-73. doi: 10.1159/000182520.
Renal handling of salt and water in the early stage of obstructive jaundice was studied in rabbits 10 days after the ligation of the common bile duct (BDL). Sham-operated (SO) animals served as controls. No sodium retention was found in BDL rabbits, despite reduced renal perfusion and elevated plasma aldosterone level. A redistribution of intrarenal blood flow was not found. The filtration fraction did not change. A saline load resulted in decreases in arterial hematocrit and total serum proteins, and increases in urine output, urinary sodium excretion and osmolal clearance. Blood pressure, glomerular filtration rate (GFR), RPF, the filtration fraction and the intrarenal flow distribution were not significantly affected by the saline load. No significant difference was found in the natriuretic response to the saline load between the BDL and SO groups. After 60 h of water deprivation, there was no significant difference in urine-to-plasma osmolality ratios or renal tissue fluid osmolality between the BDL and SO animals. The findings indicate that renal handling of salt and water was well maintained in the early phase of obstructive jaundice in rabbits. The data also suggest the critical role of the redistribution of intrarenal blood flow rather than of GFR or aldosterone in determining sodium retention in obstructive jaundice.
在胆总管结扎（BDL）10天后的家兔中，研究了梗阻性黄疸早期肾脏对盐和水的处理情况。假手术（SO）动物作为对照。尽管肾灌注减少且血浆醛固酮水平升高，但BDL家兔未发现钠潴留。未发现肾内血流重新分布。滤过分数未改变。盐水负荷导致动脉血细胞比容和总血清蛋白降低，尿量、尿钠排泄和渗透清除率增加。盐水负荷对血压、肾小球滤过率（GFR）、肾血浆流量（RPF）、滤过分数和肾内血流分布无显著影响。BDL组和SO组对盐水负荷的利钠反应无显著差异。禁水60小时后，BDL家兔和SO家兔的尿/血浆渗透压比值或肾组织液渗透压无显著差异。研究结果表明，家兔梗阻性黄疸早期肾脏对盐和水的处理功能良好。数据还表明，肾内血流重新分布而非GFR或醛固酮在梗阻性黄疸钠潴留的决定中起关键作用。
