Hishida A, Honda N, Sudo M, Nagase M
Kidney Int. 1980 Feb;17(2):223-30. doi: 10.1038/ki.1980.25.
Mechanisms responsible for renal hemodynamic alterations were studied in jaundiced (by bile-duct ligation) rabbits (BDL) 10 days after ligation of the biliary tract, in comparison with sham-operated rabbits (SO). Arterial hematocrit, plasma volume, blood pressure, abdominal inferior vena cava pressure, and heart rate were not significantly different between the BDL and SO groups. Cardiac output in BDL rabbits decreased to approximately 73% of the value for SO rabbits. Renal blood flow and GFR were reduced to 64 and 61%, respectively. Reductions in blood pressure and renal blood flow, caused by bleeding (8 ml/kg of body wt), were more marked in the BDL group than they were in the SO group. In the BDL group, the recovery of blood pressure following blood infusion was slower and the mortality was higher, There was no significant increase in the renovascular sensitivity to exogenous noradrenaline or angiotensin II in the BDL group. The findings indicate that the early stage of obstructive jaundice in rabbits was characterized by altered renal perfusion partly due to reduced cardiac output and by incrased liability to hemorrhagic hypotension.
为了研究肾血流动力学改变的机制，我们在胆管结扎10天后对黄疸（通过胆管结扎造成）兔（BDL）进行了研究，并与假手术兔（SO）进行比较。BDL组和SO组之间的动脉血细胞比容、血浆容量、血压、腹下腔静脉压和心率没有显著差异。BDL兔的心输出量降至SO兔的约73%。肾血流量和肾小球滤过率分别降至64%和61%。BDL组因出血（8ml/kg体重）引起的血压和肾血流量降低比SO组更明显。在BDL组中，输血后血压恢复较慢且死亡率较高。BDL组对外源性去甲肾上腺素或血管紧张素II的肾血管敏感性没有显著增加。这些发现表明，兔梗阻性黄疸的早期特征是肾灌注改变，部分原因是心输出量减少以及出血性低血压的易感性增加。
