Pancorbo S, Comty C
Nephron. 1982;31(1):37-9. doi: 10.1159/000182611.
The pharmacokinetics of vancomycin have been studied in 4 chronic renal failure patients undergoing continuous ambulatory peritoneal dialysis. Patients received 1 g of vancomycin in 2 liters of dialysate during an initial phase, and serum and dialysate samples were collected for vancomycin determination. 54% of the amount introduced into the peritoneal cavity were absorbed systemically during a 6-hour cycle. Peak serum concentrations averaged 23.7 microgram/ml. Mean elimination half-life was calculated to be 66.9 h, and dialysis clearance averaged 2.4 ml/min.
已对4名接受持续性非卧床腹膜透析的慢性肾衰竭患者的万古霉素药代动力学进行了研究。在初始阶段，患者在2升透析液中接受1克万古霉素，收集血清和透析液样本以测定万古霉素。在6小时的周期内，引入腹腔的药物量中有54%被全身吸收。血清峰值浓度平均为23.7微克/毫升。计算得出平均消除半衰期为66.9小时，透析清除率平均为2.4毫升/分钟。
