Rupp G H, Friedman R A
Pediatrics. 1982 Sep;70(3):437-9.
Eosinophilic nonallergic rhinitis is a newly described symptom complex reported to occur in a significant percentage of adult patients who have symptoms of perennial rhinitis. They are characterized by nasal eosinophilia, negative allergy skin tests, and a normal serum immunoglobulin E concentration. Twelve children, aged 6 to 17 years, who represent the syndrome of eosinophilic nonallergic rhinitis, have been identified. All have severe perennial rhinitis and nasal eosinophilia. Physical examination revealed pale, boggy membranes with a clear nasal discharge in ten of 12 patients. All 12 patients had a normal serum IgE concentration. All patients initially received an antihistamine-decongestant preparation with subjective improvement in seven of 12 patients. The remaining five patients were placed on a regimen of either topical or systemic steroids and all five had dramatic responses with marked improvement of symptoms. The negative skin tests and normal serum IgE help distinguish this entity from allergic rhinitis, whereas the positive nasal eosinophilia and response to steroids will differentiate eosinophilic nonallergic rhinitis from vasomotor rhinitis. Eosinophilic nonallergic rhinitis is an important cause of perennial rhinitis in children and better knowledge of this entity should lead to more aggressive and efficacious therapy.
嗜酸性粒细胞性非过敏性鼻炎是一种新描述的症状复合体，据报道在有常年性鼻炎症状的成年患者中有相当比例出现。其特征为鼻内嗜酸性粒细胞增多、过敏皮肤试验阴性以及血清免疫球蛋白E浓度正常。已确定12名年龄在6至17岁的儿童患有嗜酸性粒细胞性非过敏性鼻炎综合征。所有患儿均有严重的常年性鼻炎和鼻内嗜酸性粒细胞增多。体格检查发现，12例患者中有10例鼻黏膜苍白、肿胀，有清亮鼻分泌物。所有12例患者血清IgE浓度均正常。所有患者最初均接受抗组胺药 - 减充血剂治疗，12例中有7例主观症状改善。其余5例患者接受局部或全身用类固醇治疗，所有5例症状均有显著改善，症状明显好转。皮肤试验阴性和血清IgE正常有助于将该疾病与过敏性鼻炎区分开来，而鼻内嗜酸性粒细胞增多阳性以及对类固醇的反应则可将嗜酸性粒细胞性非过敏性鼻炎与血管运动性鼻炎区分开来。嗜酸性粒细胞性非过敏性鼻炎是儿童常年性鼻炎的重要病因，对该疾病的更多了解应会带来更积极有效的治疗。
