Mullarkey M F, Hill J S, Webb D R
J Allergy Clin Immunol. 1980 Feb;65(2):122-6. doi: 10.1016/0091-6749(80)90196-7.
We examined the differences between allergic and nonallergic rhinitis. One hundred forty-two patients were evaluated. Forty-eight patients were diagnosed as having allergic rhinitis (AR) on the basis of histories correlating with skin tests and markedly elevated total serum IgE levels. Forty-two percent of these patients had nasal eosinophilia (greater than or equal to 25%) and 58% had histories or findings consistent with asthma. Fifty-two individuals had no evidence for immunologic nasal disease, incriminated physical agents as precipitants, and demonstrated no associated respiratory pathology. These patients were classified as having vasomotor rhinitis (VMR). Twenty-one patients had symptoms similar to those of patients with VMR but they demonstrated nasal eosinophilia and were classified as having eosinophilic nonallergic rhinitis (ENR). These patients had a high prevalence of nasal polyps and were significantly more responsive to medical therapy than any group studied. It is concluded that nasal eosinophilia is of little value in the evaluation of AR but provides significant information regarding the therapy and prognosis in nonallergic rhinitis.
我们研究了变应性鼻炎和非变应性鼻炎之间的差异。对142例患者进行了评估。48例患者根据与皮肤试验相关的病史及血清总IgE水平显著升高被诊断为变应性鼻炎（AR）。这些患者中42%有鼻嗜酸性粒细胞增多（大于或等于25%），58%有与哮喘相符的病史或检查结果。52例个体无免疫性鼻病证据，将物理因素视为诱发因素，且无相关呼吸道病理表现。这些患者被分类为血管运动性鼻炎（VMR）。21例患者有与VMR患者相似的症状，但他们表现出鼻嗜酸性粒细胞增多，被分类为嗜酸性粒细胞性非变应性鼻炎（ENR）。这些患者鼻息肉患病率高，且对药物治疗的反应明显优于所研究的任何组。得出的结论是，鼻嗜酸性粒细胞增多在AR评估中价值不大，但可为非变应性鼻炎的治疗和预后提供重要信息。
